PRECURSOR LYMPHOID NEOPLASMS

• B-lymphoblastic leukemia/lymphoma
  • B-lymphoblastic leukemia/lymphoma, not otherwise specified
  • B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
    • B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
    • B-lymphoblastic leukemia/lymphoma with t(v;11q23.3); KMT2A rearranged
    • B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
    • B-lymphoblastic leukemia/lymphoma with hyperdiploidy
    • B-lymphoblastic leukemia/lymphoma with hypodiploidy
    • B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH
    • B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1
    • B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like (provisional entity)
    • B-lymphoblastic leukemia/lymphoma with iAMP21 (provisional entity)
• T-lymphoblastic leukemia/lymphoma
  • early T-cell precursor lymphoblastic leukemia (provisional entity)
• natural killer (NK) cell lymphoblastic leukemia/lymphoma (provisional entity)

 

MATURE B-CELL NEOPLASMS

• chronic lymphocytic leukemia/small lymphocytic lymphoma
• monoclonal B-cell lymphocytosis
• B-cell prolymphocytic leukemia
• splenic marginal zone lymphoma
• hairy cell leukemia
• splenic B-cell lymphoma/leukemia, unclassifiable
  • splenic diffuse red pulp small B-cell lymphoma (provisional entity)
  • hairy cell leukemia-variant (provisional entity)
• lymphoplasmacytic lymphoma
  • Waldenström macroglobulinemia
• IgM monoclonal gammopathy of undetermined significance
• heavy-chain diseases
  • μ heavy-chain disease
  • γ heavy-chain disease
  • α heavy-chain disease
• plasma cell neoplasms
  • non-IgM monoclonal gammopathy of undetermined significance (IgG/A)
  • plasma cell myeloma
  • plasma cell myeloma variants
    • smoldering (asymptomatic) plasma cell myeloma
    • non-secretory myeloma
    • plasma cell leukemia
  • plasmacytoma
    • solitary plasmacytoma of bone
    • extraosseous plasmacytoma
  • monoclonal immunoglobulin deposition diseases
    • primary amyloidosis
    • light chain and heavy chain deposition diseases
  • plasma cell neoplasms with associated paraneoplastic syndrome
    • POEMS syndrome
    • TEMPI syndrome
• extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
• nodal marginal zone lymphoma
  • pediatric nodal marginal zone lymphoma (provisional entity)
• follicular lymphoma
  • testicular follicular lymphoma
  • in situ follicular neoplasia
  • duodenal-type follicular lymphoma
• pediatric-type follicular lymphoma
• large B-cell lymphoma with IRF4 rearrangement (provisional entity)
• primary cutaneous follicle center lymphoma
• mantle cell lymphoma
  • leukemic non-nodal mantle cell lymphoma
  • in situ mantle cell neoplasia
• diffuse large B-cell lymphoma, not otherwise specified
  • germinal center B-cell type
  • activated B-cell type
• T-cell/histiocyte-rich large B-cell lymphoma
• primary diffuse large B-cell lymphoma of the central nervous system
• primary cutaneous diffuse large B-cell lymphoma, leg type
• EBV-positive diffuse large B-cell lymphoma, not otherwise specified
• EBV-positive mucocutaneous ulcer (provisional entity)
• diffuse large B-cell lymphoma associated with chronic inflammation
  • fibrin-associated diffuse large B-cell lymphoma
• lymphomatoid granulomatosis
• primary mediastinal (thymic) large B-cell lymphoma
• intravascular large B-cell lymphoma
• ALK-positive large B-cell lymphoma
• plasmablastic lymphoma
• primary effusion lymphoma
• HHV8-associated lymphoproliferative disorders
  • multicentric Castleman disease
  • HHV8-positive diffuse large B-cell lymphoma, not otherwise specified (provisional entity)
  • HHV8-positive germinotropic lymphoproliferative disorder
• Burkitt lymphoma
• Burkitt-like lymphoma with 11q aberration (provisional entity)
• high-grade B-cell lymphoma
  • high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
  • high-grade B-cell lymphoma, not otherwise specified
• B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

 

MATURE T- and NK-CELL NEOPLASMS

• T-cell prolymphocytic leukemia
• T-cell large granular lymphocytic leukemia
• chronic lymphoproliferative disorder of NK cells (provisional entity)
• aggressive NK-cell leukemia
• EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood
  • systemic EBV-positive T-cell lymphoma of childhood
  • chronic active EBV infection of T- and NK-cell type, systemic form
  • hydroa vacciniforme–like lymphoproliferative disorder
  • severe mosquito bite allergy
• adult T-cell leukemia/lymphoma
• extranodal NK-/T-cell lymphoma, nasal type
• intestinal T-cell lymphoma
  • enteropathy-associated T-cell lymphoma
  • monomorphic epitheliotropic intestinal T-cell lymphoma
  • intestinal T-cell lymphoma, not otherwise specified
  • indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (provisional entity)
• hepatosplenic T-cell lymphoma
• subcutaneous panniculitis-like T-cell lymphoma
• mycosis fungoides
• Sézary syndrome
• primary cutaneous CD30+ T-cell lymphoproliferative disorders
  • lymphomatoid papulosis
  • primary cutaneous anaplastic large cell lymphoma
• primary cutaneous peripheral T-cell lymphomas, rare subtypes
  • primary cutaneous γδ T-cell lymphoma
  • primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional entity)
  • primary cutaneous acral CD8+ T-cell lymphoma (provisional entity)
  • primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (provisional entity)
• peripheral T-cell lymphoma, not otherwise specified
• angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin
  • angioimmunoblastic T-cell lymphoma
  • follicular T-cell lymphoma (provisional entity)
  • nodal peripheral T-cell lymphoma with T follicular helper phenotype (provisional entity)
• anaplastic large-cell lymphoma, ALK-positive
• anaplastic large-cell lymphoma, ALK-negative
• breast implant-associated anaplastic large-cell lymphoma (provisional entity)

 

HODGKIN LYMPHOMAS

• nodular lymphocyte predominant Hodgkin lymphoma
• classical Hodgkin lymphoma
  • nodular sclerosis classical Hodgkin lymphoma
  • lymphocyte-rich classical Hodgkin lymphoma
  • mixed cellularity classical Hodgkin lymphoma
  • lymphocyte-depleted classical Hodgkin lymphoma

 

IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS

• plasmacytic hyperplasia PTLD
• infectious mononucleosis PTLD
• florid follicular hyperplasia PTLD
• polymorphic PTLD
• monomorphic PTLD
  • monomorphic B-cell PTLD
  • monomorphic T/NK-cell PTLD
• classical Hodgkin lymphoma PTLD